What disease commonly attacks holly and other shrubs?

Leaf spot is the correct answer because this disease is frequently observed in holly and other shrubs. It is characterized by the appearance of distinct spots on leaves, which can be caused by various fungal pathogens. The spots may vary in color, often appearing dark or tan, and can lead to premature leaf drop if left untreated. This can have significant implications for the health of the plant, as it may affect photosynthesis and overall vigor.

In contrast, while powdery mildew can affect holly among other plants, it typically manifests as a white powdery growth on the leaves rather than spots. Blight usually indicates a more severe condition that can cause rapid death of branches or stems but is not as commonly associated with the subtle spotting on leaves as leaf spot. Rust diseases also affect various types of plants, including some shrubs, but they primarily produce orange or rust-colored spores and are less common on holly. Therefore, leaf spot is the most relevant and impactful disease affecting holly and similar shrubs.